dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration
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منابع مشابه
dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS patients, although the mechanisms by which decreased dynactin 1 levels cause neurodegeneration ha...
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Running Title: Subgroups of ALS Baumann, F.1,2, Henderson, R.D.12, Ridall, P.G.34, Pettitt, A.N.4, Pamela A. McCombe1,2 1 Department of Neurology, Royal Brisbane & Women's Hospital, Queensland, Australia 2 University of Queensland Centre for Clinical Research, University of Queensland, Australia 3Department of Mathematics and Statistics, University of Lancaster, UK 4Discipline of Mathematical S...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0054511